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-loops are secondary DNA structures consisting of an RNA-DNA hybrid and a single stranded DNA that can form behind the elongating RNA polymerase II during transcription. R-loops play regulatory roles
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Description The International Max Planck Research School for Ultrafast Imaging and Structural Dynamics in Hamburg, Germany, offers a structured PhD program focusing on ultra-fast phenomena, X-ray
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soon as possible Work location: Geesthacht (near Hamburg) Application deadline: September 21st, 2025 We are looking for a highly motivated PhD candidate to investigate the interactions between wind and
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approaches in the powerful model systems zebrafish and fruit fly, and structural biology (including AlphaFold predictions and cryo-EM), we will dissect the roles of these novel mRNA export regulators and
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polyubiquitylation of relevant cellular proteins in a controlled and linkage-selective manner, as well as b) identify selectively modified substrates, the responsible enzymes and linkage-selective interaction partners
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: In higher eukaryotes, proteins that lack an apparent folded structure are enriched in many vital processes. The Lemke group studies intrinsically disordered proteins in vital cellular processes
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particular, I found that a P-body protein directly interacts with a translation initiation factor, suggesting the existence of a novel molecular “switch” capable of activating dormant mRNAs. Our lab combines
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(DSBs) in the F1 generation, where a highly enriched heterochromatin structure blocks the accessibility of homologous recombination (HR) repair machinery. This project will investigate how DNA damage in
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formation of two- and three-dimensional DNA structures which self-assemble from a number of interacting single-stranded DNA molecules. An accurate prediction of DNA structures still remains difficult, which
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structural analysis methods. A detailed analysis of the consequences of this diversification will lead to an increased understanding of the polyphilic interactions in the active site of the proteases and would