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to the refinement and application of inverse finite element (FE) modeling for multiscale mechanical characterization of cartilage. Integrate in vitro, in silico, and in vivo data into a coherent, multi-scale
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deformation microscopy, high-field MRI, clinical MRI, PET-MRI, and molecular read-outs. •Applying inverse finite element modeling (FE modeling) for the multiscale mechanical characterization of cartilage
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reflectance infrared Fourier transform spectroscopy (DRIFTS) to unravel charge transfer mechanisms, active sites and intermediate molecules in the reaction pathway. Additionally, finite element theoretical
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