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PhD studentship: Defining the role of the pioneer factor FOXA1 in hormone-dependent cancer Supervisor: Professor Jason Carroll Course start date: 1st October 2026 Project details For further
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EAF steels The transition to EAF steelmaking creates challenges for the reliable production of thin rolled steel poducts where residual element accumulation may compromise processability and properties
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chromatin profiling methods along with CRISPR/Cas9-meduated cell line engineering and various animal models. You will study the effects of the activation or depletion of chromatin-modifying enzymes using
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of cancer, namely adenocarcinoma, which was driven by a transcriptional pathway that involves Androgen Receptor (AR) and a pioneer factor called FOXA1 that helps tether AR to the chromatin. Recent new
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metallographic approaches is challenging due to the fine scale of features and limitations of stereology. Similarly, crystallographic methods such including laboratory X-ray diffraction cannot readily distinguish
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to quantify the phase fractions and lattice parameter evolution, which in turn will allow quantification of the phase transformations taking place. This approach has advantages over other methods as it utilises
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building blocks to elicit properties far beyond simple averaging over the component materials involved, instead giving exciting opportunities for new functionalities that are not found in natural materials
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production processes and are actively exploring the incorporation of new materials, technologies and designs in their operations to achieve zero-carbon construction elements. The construction industry is under
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will be tasked with the development of new models for the early detection of CIN cancers, applying bleeding edge computational methods and machine learning approaches to improve detection and
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the proteins associated with their binding sites with a view to understanding therapeutic mechanisms [e.g. see Nature Biotechnology 2023, 41 1265]. We are expanding this work to create methods to characterise