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PhD Studentship: Nanopore Technology for Rapid and Accurate Measurement of Antibiotic Concentrations
environmental surveillance and therapeutic drug monitoring. Approach and Methods: Engineer nanopores with DNA aptamers or other molecular recognition elements specific to target antibiotics Optimise sensing
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. These mobile genetic elements autonomously transfer between bacteria, disseminating resistance genes across microbial populations. Recent advances have demonstrated the potential of “counter-plasmids” that can
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: Machine Learning Molecular Dynamics. The project involves the development and application of machine learning methods that enable a major boost of the time and length scales accessible to ab-initio/first
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Methods Soft lithography and microfabrication to create defined surface landscapes. • Mating assays between resistant and sensitive Enterobacteriaceae strains. • Live-cell imaging and fluorescent plasmid
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robotic automation to identify and optimise lead compounds. This approach will serve as a test case for a generalisable platform for rapid, structure-guided antiviral discovery. Approach and Methods
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-pharmacological antifungal therapies. Approach and Methods: Develop and optimise laboratory models of fungal growth and resistance. Investigate how environmental stress factors (e.g. osmotic and nutrient stress
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techniques. The findings will lay the groundwork for clinical application and contribute to the development of targeted therapies for resistant bacterial infections. Approach and Methods Atomic force
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genomics, microbial ecology, and bioinformatics, the project will generate a curated catalogue of phages host relationships, and enzymes for future experimental validation. Approach and Methods Metagenomic
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testing, with clinical input from RNOH to ensure translational relevance. Approach and Methods: Design and fabricate porous, nanoengineered surfaces with anti-adhesive, slippery properties Characterise
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and quorum sensing, offering new strategies to overcome resistance. Approach and Methods: Use cross-linking mass spectrometry to identify peptide targets in mycobacterial membranes Study effects on cell