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structural analysis methods. A detailed analysis of the consequences of this diversification will lead to an increased understanding of the polyphilic interactions in the active site of the proteases and would
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. Accordingly, the capacity of cells to deal with replication stress is a major factor protecting us from genome instability and cancer. Yet, the molecular details of how a replication fork travels across a
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in the STEM disciplines are primarily attributable to the genius of individual visionary figures or rather to synergetic team efforts. Through a systematic analysis of at least 50 key examples from
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. Transition metal-based complexes, in particular, offer rich spin properties that can be tailored through ligand design. This project aims to explore and optimize such molecules to enhance their performance as
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field • Is fluent in English • Is interested in finding innovative, creative solutions • Has good programming/data analysis skills • Is experienced or at least strongly interested in one
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Several PhD positions (f/m/d) in International Research Training Group (iRTG) limits2vision Full PhD
support, mentoring and career development. A key component in our program are student secondments at the respective partner institute. After successful completion of the PhD, the trainee will obtain a
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particular, I found that a P-body protein directly interacts with a translation initiation factor, suggesting the existence of a novel molecular “switch” capable of activating dormant mRNAs. Our lab combines
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the Access-Repair-Restore model. Histones, an essential component of chromatin, are post-translationally modified via methylation, ubiquitination, and acetylation to regulate DDR-related chromatin functions
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on a single cell level. This includes single-cell RNAseq datasets and analysis tools, large high-dimensional flow cytometry phenotyping panels and a collection of transgenic mouse models specifically
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cytometry methods Experience with cell culture techniques is highly desired Previous experience with genomics approaches and data analysis is a plus. Interest in working in a project with wet and dry lab