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approach: integrating mechanical and enzymatic antibiofilm mechanisms into medical-grade polymers to create next-generation single-use medical consumables with built-in, robust antibiofilm properties. By
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(SONATA, EP/V028626/1) and brings together expertise in microfluidics, fluid dynamics, nanoparticle engineering, and dental microbiology. Approach and Methods: Engineer in vitro models of bacterial biofilm
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, and processing conditions influence their behaviour, creating a vast and complex landscape that traditional experimentation cannot navigate efficiently. This project addresses this challenge by bringing
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will uncover the interfacial solvation structure, validated through comparison between computed and experimental sum-frequency vibrational spectroscopies, as well as the mechanism of chemical
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Supervisors: Prof Manish Tiwari Prof Shervanthi Homer-Vanniasinkam Clinical Partner: The Royal National Orthopaedic Hospital (RNOH) Collaborator: Dr. Priya Mandal – UCL Mechanical Engineering
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microenvironment to weaken resistance mechanisms and enhance the efficacy of existing treatments. By manipulating stress responses in fungi such as Saccharomyces cerevisiae and Aspergillus nidulans, the project aims
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with experimental virologists to validate computational predictions Impact and Outlook: This project will uncover the untapped structural and functional potential of bovine UL-CDRs, laying the groundwork
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genomics, microbial ecology, and bioinformatics, the project will generate a curated catalogue of phages host relationships, and enzymes for future experimental validation. Approach and Methods Metagenomic
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mycobacterial infections. The student will characterise their mechanisms of action using cross-linking mass spectrometry and assess their effects on mycobacterial membrane integrity and cell wall metabolism
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the synergistic effects of monoclonal antibodies and colistin. Building on extensive preliminary data, the project aims to uncover the mechanisms behind this synergy using advanced biophysical and molecular