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propagate through bacterial communities while deactivating AMR genes. However, current designs are limited by scalability and complexity. This project aims to overcome these limitations by integrating large
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could be applied in biotechnology, healthcare, and environmental contexts. Employ synthetic and molecular biology tools to design and test new methods of controlling fungal behaviour. Impact and Outlook
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chemistry and nanoscale structure, these coatings will offer long-term, biocompatible protection against infection. The project will involve materials design, fabrication, characterisation, and biological
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. Synthetic analogues will be developed and screened alone and in combination with existing antimicrobials. The ultimate goal is to design novel chemotherapeutic combinations that disrupt cell wall remodelling
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rather than the structured biofilms found in real-world environments. This project investigates how engineered surface topographies influence HGT dynamics, aiming to develop design principles for materials
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from multiple disciplinary angles, with access to state-of-the-art equipment and a strong culture of innovation and mentorship. Desirable Prior Experience: Background in biochemical engineering
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-penetrating capabilities Evaluate delivery efficiency in cell-based models mimicking lung and immune tissues Identify structure–function relationships to inform rational design of future mucosal delivery
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mechanisms to guide the design and formulation of nanoparticles with superior drug delivery properties. Investigate the interaction between ultrasound, nanoparticles, and biofilms to assess antimicrobial
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significantly reduce inappropriate antibiotic use, support NHS diagnostic capacity, and enhance AMR surveillance in community settings. The platform’s low-cost, power-free design makes it particularly suitable
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nanoparticles can protect them and help deliver them precisely where they are needed. However, designing suitable AMP-nanoparticle combinations is complicated. Many formulation ingredients, concentration ratios