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principles for successful adoptive transfer of genetically modified Chimeric TCR T cells, with a focus on engineering synthetic T cell signaling circuits to instruct T cells with optimized functions for cancer
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immunotherapy using cutting-edge protein engineering with directed evolution. The lab has developed therapeutics that are currently in clinical trials, such as ST-067 (a "decoy-resistant" IL-18), MDNA-11 (CD122
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provide fresh tumor specimens and PDX models, novel engineered murine models, state of the art-AI-enabled drug screening in microtumors and cancer cells, and more. Responsibilities The Clurman lab is
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