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chromatin profiling methods along with CRISPR/Cas9-meduated cell line engineering and various animal models. You will study the effects of the activation or depletion of chromatin-modifying enzymes using
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cancer, novel genetically engineered mouse models for the depletion of different CAF populations, in vitro three-dimensional pancreatic tumour organoid/fibroblast co-culture models, CRISPR-based
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