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ultrastructural methodologies at the heart of this project using cryo-electron tomography (cryo-ET) combined with cryogenic correlated light and electron microscopy (cryo-CLEM) and cryo-focused ion beam (cryo-FIB
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distribution of defects within the specimen. At a finer scale, the microstructure will be analysed using: optical microscopy, scanning electron microscopy (SEM) for phase identification. These analyses will
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regulatory RNAs. Characterization of RNA devices by structural biology methods such as cryo-electron microscopy (cryo-EM) and tomography (cryo-ET). Testing and screening of RNA devices by functional assays in
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properties. Surface characterization will be carried out using techniques such as optical microscopy, scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD
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methods (e.g., cryo-electron microscopy, X-ray crystallography, or single-molecule techniques) and will be internationally recognized for their own research activities. Cooperation within the University
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fibrosis, in vitro and in vivo testing therapeutic candidates, scRNAseq, spatial transcriptomics, confocal and electron microscopy imaging, flow cytometry, and standard biochemical/molecular approaches. Our
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resolution x-ray crystallographic analyses, electron cryo microscopy (cryoEM), and cell-based fluidics studies. The group has access to a range of state-of-the-art facilities and technologies within the Centre
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made up of five academic departments. For more information, please visit https://www.se.manchester.ac.uk/. We are seeking an enthusiastic and proactive Senior SEM Technician to join our dynamic technical
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interdisciplinary, incorporating approaches from bacterial genetics and cell biology, genomics, metagenomics, confocal microscopy, mouse models, and pathogen evolution. Please check our lab website for more
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of Staufen1:RNA complexes in vitro; as well as on gathering detailed information of such assemblies combining light and electron microscopy approaches. Techniques Gene cloning, Protein over-expression