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transcriptional activity in relation to DNA repair dynamics. -Investigate m6A RNA methylation patterns and the role of METTL3 and m6A reader proteins in the DNA damage response. -Manipulate gene expression using
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, Methanolobus and Methanococcoides) can utilise one-carbon compounds to produce methane in diverse coastal sediments with varying sulfate availability such as saltmarshes and peatlands. Recent DNA-based studies
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enriches the large-scale patient cohorts characterized over the past decade. This approach has resulted in the discovery of how unrepaired DNA lesions persist after chemical insults, resulting in large-scale
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: (1) epigenetic analysis in a mouse models of Parkinson’s disease related exposures, (2) elucidating molecular mechanisms of pesticide-induced changes in DNA methylation in a 3D neurosphere model in
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? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description Research activities include transcriptomic and high-throughput DNA methylation
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level on DNA through epigenetic marks. Epigenetics studies molecular changes of DNA (mostly DNA methylation) in response to developmental or environmental stimuli, which does not involve a change of the
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for (including our assessment rubric); details of financial support, training, and placement opportunities available; and details of our recruitment process, can be found at https://accedtp.ac.uk/, in
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ongoing projects in the lab: (i) to understand how the MORC2 chromatin regulator impacts DNA methylation over genomic repeats in brain development, and (ii) to develop and implement a novel long read
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samples which are complemented by DNA methylation, DNA and RNA sequencing as well as clinical data. Together with the Artificial Intelligence and Cancer Evolution Division at the German Cancer Research
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changes in gene expression. Such memory is provided by epigenetic DNA or histone modifications. In plants, VEL proteins are accessory components to the histone-modifying Polycomb Repressive Complex 2 (PRC2