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long-read sequencing data (PacBio HiFi, Oxford Nanopore) Working with large-scale genomic, epigenomic (DNA methylation, chromatin accessibility), and transcriptomic datasets Contributing to genome
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computing, statistics, machine learning, programming in R/phyton, network biology, network analytics, small RNAseq, methylation, RNA-seq, DNA-seq. LanguagesENGLISHLevelExcellent Research FieldBiological
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for (including our assessment rubric); details of financial support, training, and placement opportunities available; and details of our recruitment process, can be found at https://accedtp.ac.uk/, in
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, or innate immunity. Experience with epigenetic assays (ChIP, DNA methylation) or RNA-seq workflows. Experience working in BSL-2 or higher environments. Experience with poultry handling, sampling
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enriches the large-scale patient cohorts characterized over the past decade. This approach has resulted in the discovery of how unrepaired DNA lesions persist after chemical insults, resulting in large-scale
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computational and wet bench scientists that utilize omics (e.g. genomic, epigenomic, fragmentomic, proteomic) approaches to profile tumor biopsies, circulating tumor DNA, and circulating tumor cells
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: (1) epigenetic analysis in a mouse models of Parkinson’s disease related exposures, (2) elucidating molecular mechanisms of pesticide-induced changes in DNA methylation in a 3D neurosphere model in
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., molecular cloning); cell biology approaches (e.g., immunofluorescence, RNA/DNA fluorescence in situ hybridization); routine chromatin techniques and sequencing-based technologies (e.g., RNA-seq, ATAC-seq, CUT
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involves regulation by epigenetic mechanisms at the level of DNA methylation, which can be transmitted to the next generation (2–4). However, the molecular–epigenetic mechanisms underpinning the maintenance
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novel virulence mechanism known as interspecies RNA interference (interspecies RNAi) to silence host defence genes and determine how DNA methylation regulates the activity of parasite-acquired