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includes studies of epigenetic mechanisms (DNA methylation) and their role in improving the understanding of the relationship between environment and health, including advanced statistical modelling of large
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novel virulence mechanism known as interspecies RNA interference (interspecies RNAi) to silence host defence genes and determine how DNA methylation regulates the activity of parasite-acquired
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application! Your work assignments You will work on X-inactivation and allele-specific DNA methylation in different contexts, including X-linked diseases, autoimmune disorders, and hereditary cancer as part of
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: Perform techniques such as immunohistochemistry, fluorescence microscopy, and DNA methylation sequencing to analyse neural tissues and organoids; Data Collection and Analysis: Record experimental data
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, RNA sequencing, genome-wide DNA methylation profiling; whenever possible, mass spectrometry-based (phosphor)proteomics, ex vivo drug sensitivity profiling, and spatial resolution of the immune
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members to examine how stress-inducible epigenetic changes at biosynthetic genes alter root exudation chemistry. By linking stress-induced changes in DNA methylation and chromatin accessibility to shifts in
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: Perform routine molecular biology tasks, including DNA/RNA extraction, PCR/qPCR, and preparation of reagents and buffers. Support forensic genomics and epigenetics workflows such as STR analysis
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characterization of genetically modified mice using spatial transcriptomics and gene targeting *Bioinformatic analysis of whole genome DNA methylation and expression data *Conduct chromatin profiling and analysis
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epidemiologic and biostatistical training and be proficient with R-statistical software. Prior experience with single omics data and multi-omics integration (e.g., DNA methylation, transcriptomics, proteomics
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-Aberystwyth. You will generate and analyse RNA-seq and DNA methylation data to measure homoeolog-specific expression, identify non-additive expression patterns, and examine epigenetic and structural signatures