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cell lines. Perform functional validation of CRISPR-generated driver mutants. Investigate signaling pathways associated with cancer driving mutants. Perform xenograft experiments. Generate and analyze
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technologies will be used to investigate G protein-coupled receptor (GPCR) signal transduction as it relates to cardiovascular disease, and in particular the molecular basis for ligand-mediated β2-adrenergic
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). Our lab is a highly-creative and and dynamic Drug Discovery lab involved in cutting-edge technologies collaborating internationally on projects with other labs. We specialize in GPCR signaling and
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pharmacology and using protein structure to design and screen compounds as potential drugs at various GPCR signaling pathways aimed at treating depression, pain, cancer, and various other diseases. This post
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), while the other is a fibroinflammatory adipocyte progenitors (FAPs). As their names implies APC are pre-adipocytes which given the proper signals, differentiate into mature adipocytes, while FAPs, can
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, and perspectives through merit-based processes and in alignment with all applicable laws. We believe that embracing human differences is critical to realize our vision of a healthier world, and we
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an inclusive environment that values diversity in backgrounds, experiences, and perspectives through merit-based processes and in alignment with all applicable laws. We believe that embracing human differences
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diseases including coarctation of the aorta. This work will involve processing of medical image data, creation of idealized and subject-specific computational models, and/or implementation of a computational
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that values diversity in backgrounds, experiences, and perspectives through merit-based processes and in alignment with all applicable laws. We believe that embracing human differences is critical to realize
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metabolic process Defining molecular mechanisms of T-cell mediated anti-tumor response Responsibilities Plan, design and execute complex research studies, procedures and protocols. Participate in discovery