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comprehensive differentiation studies across multiple cellular contexts, and using CRISPR activation and interference to identify specific genes that contribute to disease pathology. The successful candidate will
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neurodevelopmental disorders and brain tumors. Grounded in human biology and evolution, our work aims to uncover the molecular logic underlying human-specific neuronal differentiation and synaptic connectivity, with
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vivo studies, including analyzing patient-derived Tregs and other immune cells, differentiating Tregs and other immune cells in vitro and testing their phenotype and function, and working with humanized
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experience. Desired skills: Gene and single cell analytics experience, behavioral tests, hiPSC cell culture, stem cell differentiation, hiPSC-derivative transplant, RNA Sequencing, viral approaches, and
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3’ untranslated regions (3’UTRs) are differentially expressed across development and disease. Notably, we have shown that the Nanog 3’UTR functions as a long non-coding RNA to promote embryonic stem