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Postdoctoral position: Developing a human lymphoid organ-on-chip to evaluate candidate mRNA vaccines
. To address this issue, we developed a lymphoid organ-on-chip (LO chip) model based on a microfluidic chip seeded with human PBMC at high density within a 3D matrix. Perfusion of the SARS-CoV-2 Spike
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. We will use those nanobodies to identify stable partners of a5 receptors and in parallel we will develop proximity labeling approaches to capture transient partners. Comparison of WT and mutant cells
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. Interestingly, ILC3s also exhibit ‘memory-like’ properties that enhance their protective functions. Despite their presence in intestinal lesions, the contribution of ILC3s to inflammatory bowel disease (IBD
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such as single cells transcriptomics, spatial transcriptomics and epigenetics to characterize molecular and cellular mechanisms. Using these approaches, we previously identified an essential role
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these approaches, we previously identified an essential role for specific subsets of stromal cells in tissue repair and antitumor immunity (Dulauroy et al., Nature Medicine 2012; Stzepourginski et al., PNAS 2017
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(PPBC). We discovered that senescence plays a dual role: it is essential for tissue remodeling yet can be exploited by cancer. This establishes a critical link between regenerative senescence and tumor
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, methodological rigor. Title of the project: Genetics of brain diversity in autism Laboratory: Human Genetics and Cognitive Functions Unit (dir. Thomas Bourgeron) Duration of the contract: 2 years Aim
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with existing single-cell methods and software would represent a strong advantage. Excellent communication skills and team spirit, and an ability to work in autonomy are essential. Fluent English both
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is mostly used to make the site work as you expect it to. The information does not usually directly identify you, but it can give you a more personalized web experience. Because we respect your right
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the newly formed unit Physics of Biological Function of biophysicist Thomas Gregor. We are interested in the following topics: Precision and reproducibility of developmental processes Collective properties