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and a disulfide-rich knob mini-domain, enabling high stability and independent folding. Despite their promise, the structural and functional diversity of UL-CDRs remains largely unexplored. This project
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(SONATA, EP/V028626/1) and brings together expertise in microfluidics, fluid dynamics, nanoparticle engineering, and dental microbiology. Approach and Methods: Engineer in vitro models of bacterial biofilm
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platforms, and regulatory guidance Evaluate long-term performance and potential for clinical translation Impact and Outlook: This project addresses a critical unmet need in orthopaedic surgery by developing
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that block infection at its source, with broad applicability to respiratory pathogens, including drug-resistant bacteria. Approach and Methods: Use automated synthesis platforms to generate a high-throughput
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diagnostics, empirical antibiotic use is common, exacerbating resistance. This project aims to develop a next-generation lateral flow assay (LFA) platform for rapid, ultrasensitive detection of RTI pathogens
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interest are also welcome. Motivation to learn about nanoparticle formulation, microfluidics, or data analysis is highly valued. Motivation to work in AMR and nanomedicine and to learn how AI can guide
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£23,466 in 2026/27 rises each year) Research Training Support Grant of £5,000 to cover additional costs of training e.g. courses, project costs, conferences, travel Part-time students (minimum 50% of full