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targeting AMR gene suppression AI-driven genome design: Use LLM tools (e.g. PlasmidGPT, Evo2) to refactor plasmid genomes for enhanced manufacturability, safety, and performance Microbial validation: Test
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and a disulfide-rich knob mini-domain, enabling high stability and independent folding. Despite their promise, the structural and functional diversity of UL-CDRs remains largely unexplored. This project
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platforms, and regulatory guidance Evaluate long-term performance and potential for clinical translation Impact and Outlook: This project addresses a critical unmet need in orthopaedic surgery by developing
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: Produce recombinant viral RNAP transcription complexes in insect cells Functionally characterise RNAP activity and validate assay systems Screen fragment libraries using fluorine-based NMR spectroscopy
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that block infection at its source, with broad applicability to respiratory pathogens, including drug-resistant bacteria. Approach and Methods: Use automated synthesis platforms to generate a high-throughput
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contact them directly for informal discussion of potential project ideas. The secondary supervisor will be allocated by UCL as part of the formal admission process. Application process If you are interested
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. This project will use large-scale metagenomic mining to uncover novel phage-host associations and identify phage-encoded enzymes, such as endolysins, with antibacterial activity. By integrating evolutionary
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diagnostics, empirical antibiotic use is common, exacerbating resistance. This project aims to develop a next-generation lateral flow assay (LFA) platform for rapid, ultrasensitive detection of RTI pathogens
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Jochen Blumberger at the Condensed Matter and Materials Physics Laboratory, University College London, UK. Interested candidates may want to work on one of the following two projects. Project 1
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PhD Studentship: Nanopore Technology for Rapid and Accurate Measurement of Antibiotic Concentrations
their use in field or point-of-care settings. This project aims to develop portable, nanopore-based sensors for the rapid and accurate quantification of antibiotic concentrations in environmental and clinical