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reductions in the expression of RFC1 transcript, along with impaired RFC1 function and increased sensitivity to DNA damage from platin drugs. CRISPR/Cas9 excision of the AAGGG repeat and flanking AluSx3
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on proteomics (DNA pulldown/mass spectrometry) or CRISPR/Cas9 perturbation coupled with singe-cell transcriptomics (Perturb-seq). Promising hits identified in these screens will be further characterized
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state-of-the-art facilities in the Advanced Sensors Laboratory at Cranfield University. This will involve cutting-edge tools, including CRISPR/Cas diagnostics, paper-based microfluidics, high-throughput
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information about the total announced post-doctoral positions within in the AMBER co-fund project please visit https://www.euraxess.se/jobs/392999 . The interviews will start in April/May 2026. For more
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or equivalent in (eukaryotic) microbiology, cell physiology, bioinformatics and metabolic engineering are highly qualifying merits. Know-how of genome editing using CRISPR/Cas9, microbial cultivation/fermentation
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(IDH1/2) genes and this project focusses on how these mutations re-program liver cells, in the context of biliary cancer. We are using CRISPR-edited human cells and novel transgenic models in mice
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-edge tools, including CRISPR/Cas diagnostics, paper-based microfluidics, high-throughput single-cell analysis using droplet-based microfluidics, in collaboration with Harvard University and industrial
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genome-wide CRISPR functional screening in both mouse models and clinical samples. Working closely with computational biologists and clinicians, this interdisciplinary project offers an exceptional
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technologies, including genome engineering, functional genomics screens, and leukemia biology. More information about the Grebien Group can be found here: https://grebienlab.com https://ccri.at/research-group
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collaboration. The Choudhary lab conducts research using interdisciplinary, state-of-the-art technologies, including quantitative proteomics, next-generation nucleic acid sequencing, advanced microscopy, CRISPR