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sophisticated molecular biology tools creating receptor mutants using CRISPR and knock-downs with siRNA. We're seeking a highly motivated and curious scientist with a strong foundation in Pharmacology
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, including the production of gene-edited (knockout) poultry using CRISPR/Cas9 technology and the development of poultry lines resistant to bacterial and viral infections. Duties and Responsibilities: (70
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cells differentiation, genetic engineering with CRISPR, disease modeling, transplantation into animal models of diabetes, biomedical engineering, bioinformatics, and single-cell sequencing technologies
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. Experience with molecular biology techniques, including DNA/RNA extractions; PCR; qPCR. Knowledge of functional genetics methods (e.g. CRISPR/CAS9; transgenesis). Knowledge of model organism biology
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biology techniques including, but not limited to, PCR, protein/DNA/RNA extraction and gel electrophoresis, bacterial transformation, imaging, cloning, gene-editing (such as CRISPR), small and large scale
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to conduct functional genomics analysis in insects. The successful candidate will conduct RNAi or CRISPR/Cas9 experiments in a lepidopteran species to investigate detoxification functions. The candidate may
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aveugles des grottes. (d) Invalidation CRISPR-Cas9 ou édition de génome du gène candidat en FO (“Crispant”, et/ou dans les lignées établies), suivie de tests comportementaux visant à démontrer la fonction du
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, yeast and mammalian cells including primary cells from affected CDG patients.•The generation of cellular models using CRISPR/Cas9 gene-editing and other techniques.•Development and optimization
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funds. Continued employment is contingent on the renewal of funding. Essential Functions Assists in designing CRISPRs targeting genes associated with neurological disorders, generates CRISPR-Cas9 mutants
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responsible for assisting with various research efforts using cutting-edge CRISPR engineering tools, genetic and epigenetic screens, and a variety of novel cell and gene therapy manufacturing strategies