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experiments. Lentiviral transduction techniques for ORF-overexpression experiments or RNAi and CRISPR-Cas9 knockdown/knockout experiments. Performing detailed characterization and cellular mechanism of action
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develop and apply innovative technologies for analyzing immune memory (Krausgruber 2020 Nature), for high-content CRISPR screening (Bock 2022 Nature Reviews), and CAR T cell engineering (Datlinger 2025
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University of North Carolina at Chapel Hill | Chapel Hill, North Carolina | United States | about 11 hours ago
. Experience with genome editing technologies such as CRISPR is a plus. * For dry-lab applicants: Ph.D.-level training and research experience in analyzing multi-omics next-generation sequencing data is required
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-leading research in several fields. Notably, the groundbreaking discovery of the CRISPR-Cas9 gene-editing tool, which was awarded the Nobel Prize in Chemistry, was made here. At Umeå University, everything
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and Immunology at WashU in St. Louis to discover new pathways in the regulation of type-2 immunity. We have recently used cutting-edge CRISPR screens to identify new regulators of ILC2 and Th2 cell
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candidate will translate new insights into identifying new drug targets for improved patient outcomes in periodontal health. Dr. McCulloch’s laboratory is described here: https://discover.research.utoronto.ca
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genome editing. Your job This project aims to systematically identify and characterize regulators of early transcription termination. Potential approaches will involve pooled CRISPR screens, genome editing
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, and maintain mouse embryonic stem (mES) cells and human induced pluripotent stem (hiPS) cells, employing advanced genetic modification techniques including CRISPR/Cas9 genome editing. • Perform directed
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of this enterprise is the Center for Pediatric Neurological Disease Research (CPNDR) [ https://www.stjude.org/research/initiatives/pediatric-translational-neuroscience-initiative.html ]. The CPNDR is
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viral vectors, CRISPR-based tools and pharmacological approaches. -Perform bioinformatic analysis and integration of transcriptomic, epigenomic and epitranscriptomic datasets. -Prepare scientific reports