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in response to temperature changes identification of transcriptional regulatory networks involved in heat stress responses generation of CRISPR mutants in tomato supervising Bachelor's and Master's
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of Ect2 in PDAC patient tumours The project will use a combination of cell and molecular biology approaches (including CRISPR gene editing, western blotting, flow cytometry), advanced microscopy (live cell
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elements and regulatory factors control gene expression in both physiological and disease contexts. Current projects leverage ReLiC, a high-throughput CRISPR screening platform that we recently developed
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sorting Conduct functional cytotoxicity assays (e.g., degranulation, cytokine production, live-cell killing assays) Work with primary human NK cells and gastric cancer samples Apply CRISPR/Cas9 or base
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heterogeneity of their environments. For more details, please view www.bussilab.com and https://idmxs.org/research-theme-2/ We are looking for a highly motivated and creative Postdoc Research Fellow to join our
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, and microscopy. Experience in genetic manipulation of cells (e.g., CRISPR) is desired. Additional experience in computational biology is welcome. Ability to independently design and troubleshoot
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progression and therapy resistance. This position will leverage cutting-edge approaches including spatial transcriptomics, CRISPR-based functional genomic screening, and patient-derived xenograft (PDX) models
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the current PhD project. This will be achieved by working with primary synovial cells obtained from joints from arthritis patients (e.g., CRISPR knock-outs and phosphoproteomics signaling), in vivo arthritis
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, organoid systems together with cutting-edge functional genomics approaches routinely like ChIP-seq, CUT&RUN, PRO-seq, HiChIP, HiC, whole genome methylation analysis to advanced CRISPR-based approaches
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be seen at: https://www.crick.ac.uk/vivian-li/ . We are looking for an ambitious, collaborative and self-motivated Senior Bioinformatician to work for Dr Li’s Stem Cell and Cancer Biology laboratory