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data. We have developed in vivo single-cell CRISPR technologies to screen for dozens of molecular factors in vivo during developmental and disease. These technologies are a game-changer in the speed
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commitment) in studies in developing and/or applying cutting-edge CRISPR synthetic biology and functional genomics approaches to topics with therapeutic relevance. Some questions/challenges we are interested
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. Harsha Devalla at Amsterdam UMC invites applications for a research scientist specializing in the implementation of CRISPR-based genetic screens and gene editing techniques. This role is ideal
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the Guilliams and the Saelens team. Research Project In this research project you will apply in vivo CRISPR screens to study the functional specialization of macrophages during liver metastasis. This project is
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Post-doctoral Fellow in the Department of Orthopaedics and Traumatology, School of Clinical Medicine
research facilities at the University to develop innovative treatments. Duties and Responsibilities Design and conduct experiments involving molecular biology, genetics, and gene editing (e.g., CRISPR/Cas9
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& Biochemistry (MBB) at Rutgers University-New Brunswick. Our lab aims to understand molecular mechanisms of antiphage immunity in bacteria and archaea, focusing on the role and mechanism of CRISPR-associated
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these data and we will also analyze primary samples from patients with B cell malignancies. We will identify functions of lncRNAs using CRISPR interference, RNA pulldown experiments, mouse models, and
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-display, proximity ligation or similar. - Experience in in vivo validation of genome editing technologies. - Experience in the development of CRISPR-based or other programmable genome editing technologies
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candidate will undertake a three-year research project using a combination of expression screening techniques and loss-of-function CRISPR screening approaches with the goal of: (1) identifying substrates
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engineering (CRISPR/Cas), qPCR, and work with reporter lines carry out phenotyping, imaging, and hormone-related assays/tracing contribute to transcriptomic/proteomic experiments and integrative analysis