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details Our lab exploits both chemistry and biology to address fundamental mechanisms of genome function. While many genetic determinants of cancer are known, alternative nucleic acid secondary structures
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. However, there are very few examples of them being yet practical, because of the difficulty of realistic scale-up. Potential applications are for energy absorption and harvesting, mechanical intelligence
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, Su J, Eldridge MD, Riedel A, Serrao E, Rodewald HR, Mack M, Shields J, Cohen ES, McKenzie ANJ, Goodwin RJA, Brindle K, Marioni JC, Halim TY. (2020) ILC2-driven innate immune checkpoint mechanism
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for matching novel protein targets with their optimal expression conditions. Altogether, this project will provide new insights into the mechanisms limiting expression of challenging proteins and how
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target, since all known treatment resistance mechanisms are downstream of, and dependent on FOXA1. However, FOXA1 has been a difficult protein to study for technical reasons. We have developed a novel tool
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treatments that target AR have forced cancer cells to evade treatment and a newly characterised, but frequent escape mechanism is for cancer cells to lose dependence on AR and to take on features of a
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of materials. Applicants should be self-motivated, able to take ownership of their research, and effectively communicate their research findings. Training in all the computational and experimental methods will
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the computational and experimental methods will be provided in the projects, although relevant previous experience would be advantageous. Applications for this PhD project should be submitted via the University
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, Engineering) and should be self-motivated, able to take ownership of their research, and effectively communicate their research findings. Training in all the computational and experimental methods will be
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their research findings. Training in all the computational and experimental methods will be provided in the project, although relevant previous experience would be advantageous. Applications for this PhD project