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details Our lab exploits both chemistry and biology to address fundamental mechanisms of genome function. While many genetic determinants of cancer are known, alternative nucleic acid secondary structures
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treatments that target AR have forced cancer cells to evade treatment and a newly characterised, but frequent escape mechanism is for cancer cells to lose dependence on AR and to take on features of a
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target, since all known treatment resistance mechanisms are downstream of, and dependent on FOXA1. However, FOXA1 has been a difficult protein to study for technical reasons. We have developed a novel tool
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, Su J, Eldridge MD, Riedel A, Serrao E, Rodewald HR, Mack M, Shields J, Cohen ES, McKenzie ANJ, Goodwin RJA, Brindle K, Marioni JC, Halim TY. (2020) ILC2-driven innate immune checkpoint mechanism
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Biomedical Campus. You will join an exciting research programme investigating fundamental mechanisms of ribosome assembly, translational control and how defects in these processes drive cancer development
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, qualifications and experience required to perform the role will include a good working knowledge of fluidization, fluid mechanics and compressible flow and an interest in practical design and experimentation. It
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experience required to perform the role will include a good working knowledge of fluid mechanics and compressible flow. It will be helpful to have a working knowledge of multi-phase flows in particular
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stipend at the UKRI rate (£20,780 in 2025-26 for full time students), and a contribution towards research and training costs; A personalised training programme, to develop research, communication
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to the launch of the Bloomberg Cambridge University Corporate Bond Index later in 2025 and the delivery of the ongoing research programme related to the index project. The successful candidate will undertake desk
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technologies, bulk and single-cell RNA-sequencing, flow cytometry, multiplex immunofluorescence, and standard molecular biology and biochemistry techniques. A computational component may also be available