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. Synthetic analogues will be developed and screened alone and in combination with existing antimicrobials. The ultimate goal is to design novel chemotherapeutic combinations that disrupt cell wall remodelling
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nanoparticles can protect them and help deliver them precisely where they are needed. However, designing suitable AMP-nanoparticle combinations is complicated. Many formulation ingredients, concentration ratios
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This project will Establish mechanistic foundations for a new therapeutic strategy. Support clinical translation of antibody–antibiotic combinations. Contribute to global AMR mitigation efforts. Training and
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combining micro/nanopatterned surfaces with immobilised enzymes that degrade biofilms and disrupt microbial communication, the project aims to overcome the limitations of each individual strategy and deliver
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that suppress resistance gene transfer. Combining biophysics, microbiology, and materials science, the project will generate insights into how physical environments can be harnessed to control AMR. Approach and
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to “trick” resistant strains into becoming drug-sensitive. This interdisciplinary research combines synthetic biology, molecular biology, and biochemical engineering to pioneer sustainable, non