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single-cell level in the moss Physcomitrium patens. The project will combine cutting-edge approaches in developmental genetics, live imaging, and single-cell genomics. Research environment : The RDP
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often unguided by theory. This disorganized approach can lead to ineffective combinations or contradictory mechanisms of action (Michie et al., 2013). Their implementation must be carefully tailored
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of MEI4 will be studied by conventional and super-resolution microscopy combined with FISH. New interaction partners of MEI4 will be identified by rapid immunoprecipitation mass spectrometry of endogenous
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to develop chiral metal nanoclusters, understand their chirality at the atomic level through a combination of advanced spectroscopic techniques and theoretical simulations, and apply them to relevant processes
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properties of the latter by a combination of several spectroscopic techniques (absorption and emission in the UV/Vis and NIR wavelength range). In addition, chiral features will be added to the complexes
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the objectives and methods of the thesis project with partners and stakeholders by adopting a mixed-methods approach. The recruited person will combine participatory mapping approaches, semi-structured interviews
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to develop chiral metal nanoclusters, understand their chirality at the atomic level through a combination of advanced spectroscopic techniques and theoretical simulations, and apply them to relevant processes
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to lung inflammation and fibrosis. The student will combine structural biology, protein biochemistry, cell biology, and immunology to assess how these processes influence immune signaling proteins and their
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recruitment and secretion by the T4SS, combining four complementary approaches: Bioinformatic analysis of protein–protein interactions (PPIs), Microbiology (genetic cloning and functional secretion assays
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these phages. The candidate (M/F) will aim to characterize the molecular and dynamic parameters of filamentous phage infection, mainly using the E. coli bacterial model. To do this, the candidate will combine