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, previous studies suggest that short RNAs like eRNAs can trigger phase separation of proteins in transcriptional condensates, and transcription factors can interact directly with RNAs. The presence of eRNAs
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are three-stranded nucleic acid structures consisting of an RNA-DNA hybrid and a displaced single-stranded DNA (Allison et al., CST 3, 38-46 (2019)). They form naturally during transcription, where
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Overview Eine Druckversion dieser Ausschreibung (PDF) steht Ihnen in den weiteren Registerkarten (z.B. „Bewerbungsvoraussetzungen“) zur Verfügung. A print version of this announcement (PDF) is available in the further tabs (e.g. “Application requirements”). Programme Description Higher education...
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: In higher eukaryotes, proteins that lack an apparent folded structure are enriched in many vital processes. The Lemke group studies intrinsically disordered proteins in vital cellular processes
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of science, education, culture, economics, society, technology and the environment. The school of Mechanical Engineering and Safety Engineering, Chair of Materials Science and Additive Manufacturing (head
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sustainable bioeconomy. The four PhD projects are: Your Profile: Master’s degree (or equivalent) in computer science, applied mathematics, physics, engineering, biology, plant and agrosphere sciences
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approaches in the powerful model systems zebrafish and fruit fly, and structural biology (including AlphaFold predictions and cryo-EM), we will dissect the roles of these novel mRNA export regulators and
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polyubiquitylation of relevant cellular proteins in a controlled and linkage-selective manner, as well as b) identify selectively modified substrates, the responsible enzymes and linkage-selective interaction partners
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particular, I found that a P-body protein directly interacts with a translation initiation factor, suggesting the existence of a novel molecular “switch” capable of activating dormant mRNAs. Our lab combines
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Description TUD Dresden University of Technology, as a University of Excellence, is one of the leading and most dynamic research institutions in the country. For TUD, diversity is an essential