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structure prior to chromosome segregation, a topic they continue to investigate. Approaches include genetics, spatial genomics, single-molecule biophysics, super-resolution imaging, computational modeling
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to image and analyze the dynamics of individual chromosomes. Your work will involve high-resolution fluorescence microscopy in advanced microfluidic systems as well as adapted Hi-C protocols. Data handling
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-fate determination, genome editing, the role of chromosome structure and chromatin modification in gene regulation, and the molecular evolution of chromosome-wide mechanisms of gene control in
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and connectivity of nucleosomes in chromatin that give rise to chromosome structure in cell nuclei and biochemical reconstitutions. This involves developing supervised and self-supervised AI models
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executed, ideally involving 3D image analysis, inverse problems, or physics-informed modeling. Cryo-EM/ET and computational structural biology projects are especially relevant. Discuss results, limitations
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-scale genome assemblies and population genomic data to identify structural variants and adaptive mutations associated with genome duplication. You would be welcomed in the the Yant Lab (https
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pairs. The student will analyse a unique dataset of chromosome-scale genome assemblies and population genomic data to identify structural variants and adaptive mutations associated with genome duplication
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-fate determination, genome editing, the role of chromosome structure and chromatin modification in gene regulation, and the molecular evolution of chromosome-wide mechanisms of gene control in
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Description Biomolecular condensates have emerged as a new paradigm to understand biological functions in living cells. Dresden has pioneered research in the field of biomolecular condensates and
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Postdoctoral position to study Polo kinase and centrosome abnormalities in cancer and other diseases
approaches (e.g., super-resolution imaging, single molecule tracking, in vitro reconstitution, X-ray crystallography, and cryo-EM) to delineate the molecular bases and structural rules governing