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data in neurogenetic syndromes (including sex chromosome aneuploidies) to map effects of altered gene dosage on human brain organization. There will be a special emphasis on: use and construction
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to uncover the molecular mechanisms driving sex differences in cardiac physiology that underlie pronounced sex biases in heart disease. We focus on biological sex—the combined effects of sex chromosomes and
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circuits. We pursue a multi-disciplinary approach integrating data across biological scales in the brain, including molecular Chromosome-Conformation-Capture sequencing technologies, single-cell imaging
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strategy (PMIDs: 29123070, 33621493, 33087936, 30566856, 39947938; doi: https://doi.org/10.1101/2025.03.15.641049 ). Postdoctoral Projects Project 1: Replisome Dynamics, Replication Stress, and Cancer
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on the structure–function relationship of the bacterial chromosome. How bacteria organize their DNA and how this structure influences gene expression remain open questions. For example: How is the chromosome
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Director to advise current and new facility users on all aspects of cryo-EM analysis, from specimen preparation to data collection and cryo-EM EM image processing. The Cryo-EM Operations Director will report
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, 33621493, 33087936, 30566856, 39947938; doi: https://doi.org/10.1101/2025.03.15.641049 ). Postdoctoral Projects Project 1: Replisome Dynamics, Replication Stress, and Cancer Vulnerabilities This project aims
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to high-resolution technicolor. From deciphering the choreography of transcription complexes, chromosomes, and RNA molecules within cells to developing novel approaches to 3D molecular structure
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) and offers a wide range of support structures, including state-of-the-art light microscopy and advanced bio-image data science facilities in the outstanding Dresden environment. Tasks: Dr. Xingbo Yang’s
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circuits. We pursue a multi-disciplinary approach integrating data across biological scales in the brain, including molecular Chromosome-Conformation-Capture sequencing technologies, single-cell imaging