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Université Paris-Saclay GS Life Sciences and Health | Fontenay aux Roses, le de France | France | 18 days ago
-stranded DNA generated by these breaks. We were the first to show in yeast that strict control of these filaments is essential to prevent HR itself from inducing chromosomal rearrangements (eLife 2018, Cells
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altération de l'équilibre des populations de bactériophages (ou phages) tempérés et virulents. Les phages tempérés intègrent leur information génétique dans le chromosome de la bactérie-cible sous forme de
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include e.g. data quality controls, mapping of DNA data to reference genomes, investigation of deamination patterns, analysis of sex chromosomes, analysis of mitochondrial and Y-chromosome haplogroups
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the molecular mechanisms that initiate chromosome shattering, with a particular focus on cytoplasmic DNA nucleases that gain access to chromosomes after nuclear envelope rupture. Our work aims to define how “all
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lab at Harvard Medical School in Boston, Massachusetts. The Brugge lab has identified populations of breast epithelial cells that carry chromosome copy number alterations (CNAs) that are among the most
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chromosome numbers (aneuploidy), but malignant cells sometimes exhibit chromosomal instability (CIN): the ongoing, cell-to-cell reshuffling of chromosomes that continuously generates new tumor variants
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data in neurogenetic syndromes (including sex chromosome aneuploidies) to map effects of altered gene dosage on human brain organization. There will be a special emphasis on: use and construction
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the Job related to staff position within a Research Infrastructure? No Offer Description The project Most cancers carry abnormal chromosome numbers (aneuploidy), but malignant cells sometimes exhibit
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sarcomas, where chromosomal translocations generate fusion oncoproteins that serve as drivers of the disease. By combining a toolbox consisting of CRISPR/Cas9, RNAi technology, cellular barcoding, and mouse
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genome encodes gene expression levels. You will undertake large scale data generation from primary human samples using a method recently pioneered by the host laboratory (Hua et al., Nature 2021 https