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understanding the cellular and molecular mechanisms that govern normal and pathologic cell states in neurological and gut disorders. This position will work with animals. ESSENTIAL FUNCTIONS Isolate primary cells
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mechanisms that could be targeted to develop new therapeutic approaches. Regulation of cellular signaling by hexosamine biosynthetic pathway, O-GlcNAcylation and NF-kB transcription pathways are key areas
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of attention. The work will involve experimental techniques ranging from basic cell and molecular biology, immunology, biochemistry, to cell culture, animal studies, and patient samples. Experience with mouse
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Cryo-ET/EM postdoctoral position immediately available in Zhu Lab at Case Western Reserve University
proteins, leading to host cell pyroptosis (Science 383, 965, 2024). We invite highly motivated postdoctoral researchers to join our team. The lab has full access to cutting-edge cryo-correlative light and
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molecular mechanisms that could be targeted to develop new therapeutic approaches. Regulation of cellular signaling by hexosamine biosynthetic pathway, O-GlcNAcylation and NF-kB transcription pathways are key
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integrative analyses combining high-dimensional spatial and single-cell multiomics data to uncover novel biological insights, and translate these findings into impactful publications and presentations (15
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family pathway as well as regulation of cellular functions by other MAPK signaling pathways are key areas of attention. The work will involve experimental techniques ranging from basic molecular biology
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footprinting of the cellular proteome, and others. Opportunities exist to collaborate with current XFP beamline users and contribute to their use of X-ray footprinting towards their research projects, and to
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. Working experience using transgenic/knockout and xenograft mouse models, Cell Signaling and basic molecular biology techniques is valuable; familiarity with CRSPR/Cas9, cancer stem cells, bioinformatics
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therapy. The postdoctoral scholar will work together with additional researchers at different levels to build cellular and animal studies to elucidate the therapeutic potential of a novel molecule in solid