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We are recruiting a PhD student to integrate data-driven methods with NMR spectroscopy to enhance the characterisation of cell culture media and metabolites, increasing throughput and reducing
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alterations that relate to CHI and principally evaluate their fit as biomarkers for CHI diagnostics. This project will provide training in gene editing, iPSC technologies, and complex cell models with a focus
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the genetic, molecular, cellular, and whole systems level. Cross-cutting strengths lie in our world-leading expertise in neuroplasticity, interdisciplinary neuro-immune research, high-throughput sequencing
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in human cells, using either a human ORFeome library comprising ~14,000 barcoded human ORFs or custom libraries generated through microarray-based oligonucleotide synthesis, and identify the cellular
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PhD Studentship: The Role of O-glycosylation of the Stalk Region of the Immunoglobulin Receptor GPVI
to determine their effects on GPVI signalling. In addition, super resolution microscopy will be used to determine how glycosylation effects the distribution of GPVI on the cell membrane. Finally, nanobodies will
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the primary tumour, but these analyses relied on data derived from bulk tissue samples lacking cellular and spatial resolution. The hypothesis underpinning this project is that obesity alters
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-the-fitness-costs-of-drug-resistance-in-cancer for further information. The project aims include: Project aims Barcode a panel of cancer cell lines to enable genetic lineage tracing Design a large-scale
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engineering and nano/microfabrication Materials characterisation techniques Microbiology and cell culture Translational research and clinical collaboration Regulatory considerations for medical devices
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Methods Soft lithography and microfabrication to create defined surface landscapes. • Mating assays between resistant and sensitive Enterobacteriaceae strains. • Live-cell imaging and fluorescent plasmid
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ECM structure and function is a promising avenue for treating age-associated diseases. Another key feature of ageing is the functional collapse of cellular stress responses, pathways that ensure