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understood. This project will combine molecular, cellular, and physiological approaches to explore how exercise reprograms metabolic and inflammatory pathways that connect cardiac function to systemic health
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(metastasis). It is known that peritoneal cells contribute to the growth of metastatic tumours. Previously, it was demonstrated that an immune cell-produced metabolite promotes peritoneal tumour growth (https
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Centre for Experimental Fuel Technologies (CEFT), which aims to develop innovative fuel cell and battery technologies, underpinned by fundamental understanding. The Centre is an exciting venture bringing
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supervisory team and other research group members at the Manchester Fuel Cell Innovation Centre. Additionally, you will work in parallel with another industrial partner-funded PhD project based on liquid water
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samples lacking cellular and spatial resolution. The hypothesis underpinning this project is that obesity alters the cellular content, activation state and, critically, the spatial architecture
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at the point of commencing this post, with experience in contemporary molecular cell biology, tumour metabolism, experimental modelling and bioinformatics as applied to translational cancer genomics, ideally
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biocompatibility testing methods often overlook the biological complexity of aged soft tissue. Changes in extracellular matrix composition, immune responsiveness, and cellular senescence can significantly alter how
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will combine 2 and 3D cell culture systems, gastruloids development, FACS drug screening and next-generation sequencing with investigation of patient samples, to identify and characterise targetable
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About the Role Join a multi-disciplinary team that explores human intestinal development and disease using cutting edge single cell and spatial biology technologies, organoid models and
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, osteosarcoma) cell and time of origin is debated but experimental studies in different models suggest possible in utero induction with postnatal initiation similar to leukaemia. In Ewing sarcoma, FET::ETS gene