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to the interior of the cell. GPCRs are involved in multiple physiological process including cell growth, neurotransmission, metabolism & immune response; they can misfunction in disease and consequently have served
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-the-fitness-costs-of-drug-resistance-in-cancer for further information. The project aims include: Project aims Barcode a panel of cancer cell lines to enable genetic lineage tracing Design a large-scale
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PhD Studentship: The Role of O-glycosylation of the Stalk Region of the Immunoglobulin Receptor GPVI
to determine their effects on GPVI signalling. In addition, super resolution microscopy will be used to determine how glycosylation effects the distribution of GPVI on the cell membrane. Finally, nanobodies will
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in human cells, using either a human ORFeome library comprising ~14,000 barcoded human ORFs or custom libraries generated through microarray-based oligonucleotide synthesis, and identify the cellular
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, the cytocompatibility of these materials, as well as their ability to promote tissue healing and growth will be assessed in 2D and 3D in vitro cell culture. Methods The hybrid foldamer-polymer scaffolds will be
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AIEC and the microbiome and how this affects the gut epithelium. In this project, we will unravel AIEC-microbiome crosstalk and its impact on inflammation in CD by applying a microaerobic intestinal cell
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PhD Studentship: Decoding Campylobacter pathogenesis in chickens: From colonisation to contamination
Campylobacter colonisation and translocation across the gut epithelium. By exploring host cell interactions of C. jejuni isolates with high and low transmission risk at a cellular and molecular level, the student
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preclinical mouse models and stool samples collected from patients with myeloma. In parallel, the project will explore how these changes impact immune cell populations and responses to infection. To do
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that regulate cellular metabolism which have potential therapeutic application in a wide variety of human disease conditions. In support of this, the compounds you generate will be evaluated by other team members
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have been described, including inducing DNA damage, modulating the immune system, and impacting cellular control pathways [2] (https://doi.org/10.1099/jmm.0.001817 ). The candidate will investigate