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project focusing on a long-standing and fascinating question : « what makes our brain cells human ? » (see our recent work : Hecker et al. Science 2025; Libé-Philippot et al. Cell 2023; Vanderhaeghen and
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to unravel how plants control gene expression across different tissues and stress conditions by combining single-cell genomics, artificial intelligence, and synthetic biology. Apart from shedding light on
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and stress conditions by combining single-cell genomics, artificial intelligence, and synthetic biology. Apart from shedding light on the fundamental aspects of transcriptional control, this project
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, transcriptomics, proteomics, metabolomics, single cell and/or genotyping data. Microbiology techniques is a plus but not required. Experience in molecular biology techniques for processing and analysis of DNA and
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developmental biology, cell biology and evolutionary biology. We like to implement novel omics technologies such as single cell approaches and chemical biology to help us answering our biological questions
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method, can engineer thousands of defined mutations in parallel in a single test tube in yeast. Strains are tagged by DNA barcodes, allowing to efficiently track mutations in cell populations during
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question: « what makes our brain human ? » (Vanderhaeghen and Polleux, Nat. Rev. Neurosci. 2023). We combine cutting-edge approaches such as pluripotent stem cell models of human corticogenesis, human-mouse
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including fragmentomics, methylomics, etc). In addition, results will be compared and integrated with bulk and single-cell/spatial data obtained on matching tumor cells. About TOBI-lab The overarching goal
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project that combines cutting-edge approaches including state-of-the-art imaging techniques, pluripotent stem cell models, in vivo mouse models of neurological disorders, drug (brain) delivery and nanobody
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. At our Center, researchers study the cellular mechanisms of health and disease in the central nervous system. The De Wit lab (Laboratory of Synapse Biology) at the VIB-KU Leuven Center for Brain & Disease