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achieved 1) biochemically, via networks of interacting polarity proteins, 2) mechanically, via active transport of components from one side of the cell to another, or 3) mechanochemically, by the integration
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p53 pathway. Interestingly, suppression of the cell cycle checkpoint may not be the only pathogenic mechanism supporting the transformation of cells lacking p53 or overexpressing PPM1D. In this project
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Institut de Psychiatrie et Neurosciences de Paris (IPNP) | Paris 15, le de France | France | 2 days ago
observations of cell-cell fusion events. The project will be done in close collaboration with Grégory Lavieu’s lab (https://u-paris.fr/lavieu-lab/ ). References [1] Jackson, C. B., Farzan, M., Chen, B. & Choe, H
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Cellular Biology The postdoctoral researcher in cellular biology will study the molecular and cellular mechanisms controlling lipid synthesis, storage, and mobilization, as well as inter-organelle
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Qualifications Background in tendon or musculoskeletal biology Familiarity with ECM biology, cell–matrix interactions, and inflammatory signaling pathways Experience in mechanical testing and biomaterials
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biology. The project aims to uncover how mechanical properties, forces, and physical phenotypes integrate with molecular networks to regulate the function of complex cellular systems across multiple
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cytoskeletal crosslinker required for mechanical stability and signaling in skeletal muscle and heart. Mutations in the plectin isoform P1f cause limb-girdle muscular dystrophy accompanied by progressive
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Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity. Immunity 2019 50(5):1188-1201.e6. APPLY HERE: https://www.img.cas.cz/phd Where to apply Website
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response (DDR) mechanisms. DDR orchestrates the detection and repair of DNA lesions, activation of cell-cycle checkpoints, and the repair of both double-strand (DSBs) and single-strand DNA breaks
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. Responsibilities include but are not limited to the following areas: Conduct cutting-edge research to elucidate cellular and molecular mechanisms underlying stem cell regulation in the context of regeneration, aging