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Field
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adults, characterised by severe genomic instability and a lack of targeted therapies. Using cutting-edge methods and unique primary patient-derived cell models, this project will seek to understand
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testing (e.g. cell culture and organoid models). As part of a third-party grant from the Federal Ministry of Education and Research, the BfR is working in collaboration with the University of Veterinary
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to characterise mice in terms of their cognitive, social and emotional behavioural spectrum Molecular and cell biology analyses of neuroplasticity, endocrinology and immunology using established techniques (e.g
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”, which aims to functionally validate newly identified genetic variants that regulate quantitative spermatogenesis. This integrative project combines GWAS, bulk and single-cell transcriptomics, protein
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practical expertise in protein biochemistry, molecular biology, or cell biology Strong interest in basic and translational cancer research, Team player, who thrives by working in interdisciplinary teams
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chromatin organization and non-coding RNAs influence gene expression and define the phenotype of vascular cells and tissues. We are particularly interested in the behavior of endothelial cells during
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include in detail: Experimental work in vitro to investigate mixtures with human cell lines and organoids in microphysiological systems (MPS) Systematic testing of whole mixtures and single substances and
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database and literature review to extract relevant co-exposure scenarios for in vitro testing Experimental work in vitro to investigate mixtures with human cell lines and organoids in microphysiological
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, treatment, and prevention of human diseases (e.g., Li et al., Nature Metabolism, 2024; Ni et al., Cell Metabolism, 2023; Leung et al., Science Translational Medicine, 2022; Seelbinder et al., Nature
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. Such structures can be used to construct artificial cell mimics and new materials. A scaffold-free DNA tile assembly is a programmable method for the formation of two- and three-dimensional DNA structures which