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Transfer (LET) alpha-particles to cancer cells, maximising efficacy while minimising toxicity. Knowledge about radiation sensitivity, accrued mainly with sparsely ionising low-LET radiation (e.g. X-ray
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, the race is on to understand how these DNA changes affect disease progression and post-operative recurrence risk. This PhD project uses CRISPR/Cas9 to examine risk variants in patient-derived cells and
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Gregory Hamm (AstraZeneca). Project details The tumour immunity cycle involves cyclical trafficking of T cell subsets between the tumour and lymphoid organs. While current immunotherapy has focused on re
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Cambridge Institute (CRUK CI), to investigate the molecular mechanisms of small RNA-mediated chromatin silencing. As a whole, the Hannon laboratory has broad interests that range from discovery research
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Discipline: Engineering & Technology, Materials Science, Mechanical Engineering Qualification: Doctor of Philosophy in Engineering (PhD) This project is a collaborative research effort between
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earlier as well as understand the mechanisms driving CIN. This project will aim to build upon previous work within the group developing computational methodologies to detect and deconvolute the mutational
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treatments that target AR have forced cancer cells to evade treatment and a newly characterised, but frequent escape mechanism is for cancer cells to lose dependence on AR and to take on features of a
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details Our lab exploits both chemistry and biology to address fundamental mechanisms of genome function. While many genetic determinants of cancer are known, alternative nucleic acid secondary structures
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. However, isothiocyanates have been shown to possess hormetic effects (stimulation at low doses and inhibition at high doses) on cell growth. We have shown that high doses of isothiocyanates have anti-cancer
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). On the other hand, fuel cells have been more popular in recent years, especially in transportation applications due to their high energy density and capability to operate in a wide temperature range. To have