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both chemistry and biology to explore fundamental mechanisms of genome function (http://www.balasubramanian.co.uk ). Our projects involve developing and using cutting edge technologies in chemical
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chromatin profiling methods along with CRISPR/Cas9-meduated cell line engineering and various animal models. You will study the effects of the activation or depletion of chromatin-modifying enzymes using
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: Advanced molecular and protein analysis Mass spectrometry-based imaging Multi-omics technologies Preclinical cardiometabolic animal models They will also gain professional development in data stewardship
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-energizing exhausted T cells, it is becoming apparent that many checkpoint drugs act on specific subsets of ‘stem like’ T cells, which are present in the lymph nodes, or other sites such as the tumour itself
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both sites. The project sits at the interface of cell line engineering, protein science and machine learning and you will receive advanced training in these areas while developing methods to accelerate
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are the defining and driving mediators in these two major cancer types. Since FOXA1 is the 'foundation block' of the ER and AR pathways in breast and prostate cancer, respectively, it has been an attractive drug
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neuroendocrine cancer, which is termed Neuroendocrine prostate cancer (NEPC). It is not entirely clear what replaces AR as the driver, but recent evidence has suggested that neuronal transcription factors such as
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technologies, bulk and single-cell RNA-sequencing, flow cytometry, multiplex immunofluorescence, and standard molecular biology and biochemistry techniques. A computational component may also be available