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replication and transcription. Using C. elegans genetics, advanced RNA biology techniques, and industrial biochemistry training with Inspiralis Ltd., the student will investigate how RNAs and their
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recently (~50,000 years ago), there were many other types of humans on earth, including Neanderthals and Denisovans. What was it about modern human biology—if anything—that set us apart from these extinct
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to alternative splicing. This PhD offers the scope to develop independence – pursing promising leads on interesting biology – while addressing one of evolution’s most longstanding challenges. Beyond advancing
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genetic adaptations (‘genetic swamping’). Training The student will receive broad training in molecular biology, historical DNA, genomics, bioinformatics and population genetics. The student will take part
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been enhanced through predictive structural biology tools such as AlphaFold, which allow accurate prediction of effector structures from primary sequence. We recently identified a number of immune
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the student with training in diverse techniques related to molecular and cellular biology, bioinformatics and protein biochemistry. A key activity in this project will be the use of targeted reverse genetics
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. Approaches and goals: The overarching goal is a molecular-level understanding of this important but understudied family of molecules achieved through a multi-disciplinary approach encompassing cell biology
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: Ahola et al. Trends in Cell Biology 2024 doi: 10.1016/j.tcb.2023.06.002. Ahola et al. Cell Metabolism 2022 DOI: 10.1016/j.cmet.2022.08.017
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Main description: Native mass spectrometry is an expanding structural biology tool to elucidate the function of protein complexes. Excitingly, the demand for this technology is increasing. However
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autophagy and the innate immunity response. Using cutting-edge omics (transcriptomics/proteomics), advanced imaging (confocal) and cellular biology approaches (macrophages, autophagy biomarkers), this project