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to “trick” resistant strains into becoming drug-sensitive. This interdisciplinary research combines synthetic biology, molecular biology, and biochemical engineering to pioneer sustainable, non
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production and capable of suppressing AMR gene dissemination in clinical and environmental settings. Approach and Methods: Synthetic biology: Construct modular conjugative plasmids with engineered payloads
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techniques Microbiology and molecular biology Enzymology and antimicrobial screening Training will take place across three state-of-the-art laboratories, with opportunities for collaboration, publication, and
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/population genetics (van Dorp Lab) • Environmental microbiology, phage biology and metagenomics (Santini Lab) Both labs promote open research culture and have a strong track record of PhD supervision
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learning and machine learning for biological data Sequence and structure analysis of large-scale datasets Functional annotation and evolutionary analysis Collaborative research with experimental virology
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: Structural biology, including cryo-EM Biochemical assay development Medicinal chemistry and lead optimisation NMR spectroscopy and fragment-based drug discovery Machine learning and active learning
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Student Development The successful applicant will gain expertise in: Biophysical imaging (AFM, microscopy) Microbiology and molecular biology RNA sequencing and data analysis Interdisciplinary collaboration
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PhD Studentship: Nanopore Technology for Rapid and Accurate Measurement of Antibiotic Concentrations
environments. Training and Student Development: The student will gain hands-on experience in: Molecular biology and aptamer engineering Nanopore fabrication and single-molecule sensing Data acquisition and
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chemistry and nanoscale structure, these coatings will offer long-term, biocompatible protection against infection. The project will involve materials design, fabrication, characterisation, and biological
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, biochemistry, materials engineering, or related disciplines Interest in enzymology, biofilms, materials science, and interdisciplinary research Laboratory experience in molecular biology or materials