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compounds, with notable examples including penicillin, lovastatin, and ciclosporin. Advances in genome sequencing and bioinformatics have revealed that fungal genomes contain numerous biosynthetic gene
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and Environment (A-LIFE) at the Vrije Universiteit Amsterdam invites applications for an exciting PhD position that will combine innovative bioinformatics and genomic tools to study genomic
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approach where the same molecule interferes in different biological pathways is a promising strategy. Conditional AI for de novo molecule design may be applied in such case. New “conditional” generative
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Primary Supervisor: Dr Jose De Vega Scientific Background: Interspecific hybridisation is a common mechanism of diversification in plants, unlike in animals, largely because plants can overcome
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, such as enhanced tolerance to drought and salinity. In the face of rapid environmental change, understanding how different organisms respond to shifting conditions is more important than ever. Despite
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through the body and reach the brain, carrying RNA, proteins and metabolites. This project will investigate whether BEVs differ between postmenopausal women with high and low cognitive performance, and how
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undertake fieldwork (optional) to collect samples and extend the fitness database, molecular work to sequence additional genomes, and bioinformatics to define mutation-effect scores, thus generating
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preliminary research questions include: Do antibiotics sorb to and accumulate on microplastics, increasing AMR selective pressures? Do microplastic polymers differ in their ability to support growth
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be applied to real-life situations through: two rotation projects - both allied with but in different disciplinary areas related to the PhD project. three taught units - training in Statistics
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on discovery of next-generation immunotherapy for kidney cancer through different state-of-the-art approaches integrating multi-omics and translational immunology. You must hold a MD or MSc/Masters’ degree in