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of rejuvenation strategies. We have established a large dataset of single cell whole transcriptomic analysis of hematopoietic progenitors and bulk RNAseq of endothelial cells from different mouse models with
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enzyme engineering. The PhD project will involve bioinformatic selection of candidate enzymes, employing a combination of ‘off-the-shelf’ tools based on both sequence and structure. These enzymes will be
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mimicked with in vivo models of metastasis, which provides unique opportunities to mechanistically dissect what drives the different cell states. You will link clinically relevant phenotypes to putative
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bioinformatic skills to predict the evolution of rare diseases? FSHD is a rare neuromuscular disorder. No approved treatment is currently available. Slow and variable disease progression complicate trial design
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mimicked with in vivo models of metastasis, which provides unique opportunities to mechanistically dissect what drives the different cell states. You will link clinically relevant phenotypes to putative
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) in the 5' untranslated region (5'UTR) of HIV-1. Although pro- and antiviral effects have been described, its exact role in the different RNA isoforms remains poorly understood, as short read sequencing
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machinery) to conduct new catalytic tasks through a combination of chemical intuition and enzyme engineering. The PhD project will involve bioinformatic selection of candidate enzymes, employing a combination
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diagnosis, and therapy of diseases like cardiovascular diseases or cancer. Overall, the institute strives to advance precision medicine by combining knowledge from different fields such as biology, chemistry
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consumers. You'll gain deep interdisciplinary experience—combining multiple data layers and approaches including bioinformatics, machine learning, food safety management, regulatory science, genomics and user
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diagnosis, and therapy of diseases like cardiovascular diseases or cancer. Overall, the institute strives to advance precision medicine by combining knowledge from different fields such as biology, chemistry