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-derived neurons that generalize over different patients. To test candidate intervention strategies that normalize these phenotypes. In addition to these core activities, you will perform bioinformatic
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machinery) to conduct new catalytic tasks through a combination of chemical intuition and enzyme engineering. The PhD project will involve bioinformatic selection of candidate enzymes, employing a combination
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that upregulate STXBP1 expression. To establish cellular phenotypes in patient-derived neurons that generalize over different patients. To test candidate intervention strategies that normalize these phenotypes. In
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and outside the project. Required educational backgroud A MSc degree in technical medicine, bioengineering, biomedical science, immunology, biotechnology, (bio)analytical chemisty, bioinformatics
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novel as well as state-of-the-art methods to map and functionally characterize RNA structure ensembles under different cellular conditions. Explore the therapeutic potential of targeting RNA structure