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world-leading researchers from Oxford, Harvard, and other premier institutions to develop innovative gene-silencing and gene-editing technologies targeting the underlying causes of genetic heart diseases
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into disease progression, with the ultimate aim of identifying novel biomarkers and therapeutic targets. You will hold a relevant PhD/DPhil, together with sufficient specialist knowledge in normal and malignant
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to the development and implementation of strategies/action plans (and ongoing review) to ensure that targets are met according to study timelines. Supervision would be provided by senior Centre staff, including
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in preventing immune-mediated pathology in autoimmunity remains poorly understood. Using genetic and antibody-based targeting, we aim to dissect how these pathways modulate T-cell signalling
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characterising binding interactions. You will drive the completion of several mature projects to publication, including revealing new roles for disordered domains in efficient DNA target search. You may also
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precancers and developing targeted interventions, including vaccines, to intercept them. The project focuses on designing, validating, and preclinically testing neoepitope-based mRNA vaccines to prevent BRCA
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renewable award. You will lead a programme of research in the molecular mechanisms of cardiovascular disease, that may include a range of approaches including targeted genetic murine models, primary cell
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facilely applied as a photoluminescent layer, targeting in situ detection and non-contact visualization of surface temperatures and pressures. You should hold a PhD/DPhil (or near completion*) in materials
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culture and organoids to ensure data is clinically relevant. Our overarching aim is to utilise these techniques to identify therapeutic targets to which we can generate effective treatments. The post would
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. By focusing on unique cell-specific receptors, outcomes will inform the development of targeted drug delivery strategies utilizing RNA therapeutics. This research will contribute to a deeper