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compartments. The aim of these studies is to identify host-targeted therapies that improve clinical outcome when initiated after the onset of critical illness, when many patients present for care. Fundamental
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folding, gene regulation, drug–target interactions, and multi-scale biomedical modeling. 3. Deep Learning on Graphs with Higher-Order Structures This project develops neural architectures capable
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malignancies. Leukemia. 2023;37(4):864-876. Kumar S, Schoonderwoerd MJA, Kroonen JS, et al. Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell
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challenging research and work in a highly collaborative manner. Projects will discover potential new targets to guide the personalized treatment of devastating human cancers of unmet need. For more information
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proteins with regard to their role in the development of cancer, the emergence of therapy resistance, as predictive markers to guide therapy and as therapeutic targets. Your Responsibilities Independent
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-pathogenic fungi and identifies targets for the development of novel natural product-based antibiotics. The junior research group Metabolomics-guided Natural Product Discovery (https://www.leibniz-hki.de/de
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and their microenvironment, with a focus on immune cells, stromal components, and their metabolic communication. One central aim is to identify novel therapeu-tic targets for next-generation immune and
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of Gram-negative bacteria. The studied targets represent both soluble proteins and membrane bound complexes. These proteins are vital for the survival of the bacteria and interesting targets for novel
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-pathogenic fungi and identifies targets for the development of novel natural product-based antibiotics. The junior research group (Epi-)Genetic Regulation of Fungal Virulence (https://www.leibniz-hki.de/en/epi
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of endocrine physiology and regulation Clinical validation in patients and clinical trials using innovative approaches Identifying targets for the development of new pharmacologic therapies Drug discovery