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of compounds that inhibit a critical protein target that will lead to drugs for currently untreated cancer types. It employs cutting-edge structure based drug design and property-based optimisation approaches
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, maintenance of the cellular environment, behaviour and immunity. Carbon dioxide is a strategically important research target for crop responses to environmental change, insect-borne disease and public health
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evidencing: which scientific discoveries are more impactful than others; whether public attitudes to science change over time; how the public learn and talk about science; how different target groups respond
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postholder will undertake quantitative petrological research to investigate magma storage conditions and timescales of magmatic processes in the lead up to and during selected volcanic eruptions of target
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future research into brain-based biomarkers and to (iii) genomic variation, using novel imaging-transcriptomics approaches, e.g., to identify putative treatment targets. To this aim, the successful
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advanced patient-derived tumour models and use them to test promising therapeutic targets that exploit vulnerabilities caused by loss of the SMARCB1 gene. This role offers an excellent opportunity to further
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for their expression in plant colonizing bacteria and integrating them into the chromosomes of appropriate chassis. Control systems will be designed to restrict expression to target plants and ensure optimal expression
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the possibility of making “universal” vaccines by targeting these epitopes. We have validated this methodology for the influenza virus (https://www.nature.com/articles/s41467-018-06228-8) and the technology has
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Institute for Molecular and Computational Medicine (IMCM). You will test GSK assets and targets in established models of podocyte and mesangial cell pathology relevant to glomerular diseases. You will
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amenable to therapeutic targeting. This position will involve the application of advanced data science approaches to explore large-scale clinical datasets extracted from electronic health records, with