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that target diverse biological processes. These include DNA replication, transcription, translation and cell signaling. To exemplify, nucleoside analogues possess an accomplished history within therapeutic
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brain development, how brain changes relate to patient symptoms and how to best target treatment. This project seeks develop tools to better understand, diagnose, monitor and target in children with
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planned acts, such as targeted terrorist activities. This exciting project will focus on developing a mathematical model (and a supporting research software) to predict the key performance indicators of a
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), patent applications and commercialisation (e.g. UoE spinout, MitoRx Therapeutics ). Here, you will design, synthesise and characterise novel potential drug structures to target intracellular structures
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Agrobacterium-mediated transient expression in Nicotiana benthamiana. This will test whether minibinders are able to disrupt and ameliorate the known phenotypes of their target effector. We anticipate
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the student with training in diverse techniques related to molecular and cellular biology, bioinformatics and protein biochemistry. A key activity in this project will be the use of targeted reverse genetics
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’, adopting distinct structural forms each tailored to functionally specific downstream targets. Initial cryo-electron microscopy (cEM) studies show that MRFAP1 forms a remarkable dodecameric ‘nanocage’ which
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, hosted at the Universitat Politècnica de València) and SLATE (Software for Linear Algebra Targeting Exascale, hosted at the University of Tennessee at Knoxville). By the end of the PhD, the student will
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explore ways to control their motion in 3D space. Synthetic microswimmers have many potential biomedical applications, including targeted drug delivery and non-invasive medical treatments. The swimmers
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sensing (e.g., PlanetScope, Sentinel-1), advanced numerical modelling (HEC-RAS, Delft-FM), and targeted field surveys to map mining intensity, simulate channel adjustment, and assess changing flood hazards