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biochemical reconstitution, electron cryomicroscopy (cryo-EM), advanced bacterial genetics, and phage biology to explore how cells and viruses control the three-dimensional structure of DNA. We investigate how
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at the Department of Biochemistry. You will be working on a project that will study the functional importance and prevalence of filamentation among transcription factors at the structural level. The project has a
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relevant skills acquired and will also be determined by the funding available. About you Applicants will hold a PhD/DPhil or be near completion of a PhD/DPhil in a subject relative to Structural Biology
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in Mass Spectrometry and Structural Glycobiology to work under the supervision of Prof. Weston Struwe for a period of 24 months. The project, funded by the UKRI, centres on developing advanced methods
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methodology, theory, and applications across the areas of Bayesian experimental design, active learning, probabilistic deep learning, and related topics. The £1.23M project is funded by the UKRI Horizon
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inhibitors and bifunctional molecules Experience in using structural guidance for ligand design Experience in cell viability and lysis assays, fluorescent reporter assays, flow cytometry, CETSA, ELISA, Western
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generate key structural and biophysical data to support the design of small molecule inhibitors with particular focus on protein production and crystallisation, solving protein-ligand structures, fragment
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Prevention Initiative (COPI). The successful applicant will develop the simulation model capabilities using the PRIMEtime structure to estimate the impacts of the suite of interventions being implemented in
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for carrying out research to develop iPSC-derived lung cell models. Working within a team of biochemists, cell and structural biologists, you will perform experimental work to apply omics technologies, advanced
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and structural biology of rhomboid-like membrane proteins. You should hold a PhD/DPhil in a topic relevant to structural biology and biochemistry, together with relevant experience. You should be able